Background Follicular helper T (TFH) cells induce germinal center response to produce high affinity antibodies against a specific pathogen. Excessive formation of TFH cells are closely associated with ...

Background Cellular immune responses are phenotypically and functionally perturbed in patients with lupus nephritis (LN), leading to severe renal tissue inflammation. Although multiple gene expression ...

Background Systemic lupus erythematosus (SLE) is about 10 times more common among women than men. This sex bias was previously attributed to sex hormones. However, while sex hormones are abnormal in ...

Background Recent advances in the treatment of systemic lupus erythematosus (SLE) have focused on inducing specific immune tolerance to avoid complications from the long-term use of immunosuppressive ...

Objective Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) symptoms, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research on ...

Background Systemic Lupus Erythematosus (SLE) is a prototypic, systemic autoimmune disease that can affect many organs. Current treatment of SLE is largely empirical, while the existing ...

Topical calcineurin inhibitors in cutaneous lupus erythematosus In the management of cutaneous lupus erythematosus (CLE), topical calcineurin inhibitors have recently been established as the ...

Background Many investigators have explored pathways upregulated in SLE and CLE. Few reports studied key downregulated pathways and mediators. Using unbiased proteomic technique, we have previously ...

Systemic lupus erythematosus (SLE) is a heterogeneous disease characterised by abnormalities in cellular and humoral immunity with clear hints that abnormalities of B lineage cells (B and plasma cells ...

Background Zetomipzomib is a first-in-class selective inhibitor of the immunoproteasome that offers anti-inflammatory properties without significant immunosuppression. 1 2 Methods The MISSION study is ...

Background Pregnant women with antiphospholipid antibodies and/or lupus have higher rates of adverse pregnancy outcomes (APOs), such as fetal loss and preterm birth due to severe preeclampsia (PE) or ...

Objective Our study aimed to identify correlations concerning the controversial relationship between serum interleukin (IL)-17A and IL-6 levels and their associations with SLE activity and organ ...