Membrane trafficking is the process by which proteins and other macromolecules are distributed throughout the cell, and released to or internalised from the extracellular space. Membrane ...

This important study offers convincing evidence that intra-Golgi transport slows from cis to trans and varies between cargos even within the same cisternae, supporting a more stable compartment model.

In the manuscript by Tie et.al., the authors couple the methodology which they have developed to measure LQ (localization quotient) of proteins within the Golgi apparatus along with RUSH based cargo ...

In the secretory pathway, the pH within organelles is gradually acidified, starting at 7.1 to 7.2 in the endoplasmic reticulum, decreasing to 6.0 to 6.7 in the Golgi apparatus/trans-Golgi network ...

Heart failure is a global health issue with significant mortality and morbidity. There is increasing evidence that alterations in the gastrointestinal microbiome, gut epithelial permeability, and ...

Endosome, endoplasmic reticulum (ER), Golgi markers, and HIV-1 proteins were identified by proteomic assays in isolated conduits. Both the ER and Golgi showed elongated and tubular morphologies that ...

These mutations prevent the regulated transport of UBIAD1 from the endoplasmic reticulum (ER) to the Golgi, which leads to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) ...

public3.bta.net.cn, dolphinyahy{at}hotmail.com Background and aims Golgi protein 73 (GP73) as a potential serum marker for hepatocellular carcinoma (HCC) has not been validated in large cohort studies ...

Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, U.K., Department of Chemical Engineering, University College London ...

Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise ...

Introduction: Influenza infection is a significant threat to public health, and identifying dynamic biomarkers that influence disease progression is crucial for effective intervention. Methods: We ...