Suddenly falling asleep mid-sentence, while driving or even passing out without warning is a common scene of comic relief in sitcoms, but for people living with narcolepsy in real life the condition ...

Liblau and Joseph S. Takahashi) This work shows that the amidated terminal ends of the secreted hypocretin (HCRT) peptides (HCRT NH2) are autoantigens in type 1 narcolepsy, an autoimmune disorder ...

1 Department of Cell Systems and Anatomy, The University of Texas Health San Antonio, San Antonio, TX, United States 2 Department of Obstetrics, The Second Xiangya Hospital, Central South University, ...

However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize ...

Alkermes plc (Nasdaq: ALKS) today announced plans to present new research related to ALKS 2680 at SLEEP 2025, the 38th annual meeting of the Associated Professional Sleep Societies (APSS), taking ...

New Research Evaluating the Clinical, Economic and Humanistic Burden of Narcolepsy and Findings From ... downstream wake-promoting pathways that project widely throughout the brain.

Here, we demonstrate that inhibition of the p38 MAPK-MK2 signaling pathway sensitizes cancer cells to MTA treatment. We utilize CMPD1, a dual-target inhibitor, to concurrently suppress the p38-MK2 ...

1 First People’s Hospital of Jinzhong, Jinzhong, Shanxi Province, China 2 First Hospital of Shanxi Medical University, Taiyuan, Shaanxi, China The final, formatted version of the article will be ...

while pathways pertaining to collagen synthesis and extracellular matrix organization were upregulated. These findings and the altered bioenergetic profile indicative of mitochondrial dysfunction ...

Narcolepsy can be a scary thought on its own, but if you throw being pregnant into the mix it can come with a plethora of concerns, risks, and precautions. Narcolepsy not only effects your daily ...