Methods ILC1, ILC2 and ILC3 cells were determined and characterised by confocal microscopy and flow cytometry in ileal and BM biopsies, in peripheral blood (PB) and SF mononuclear cells obtained from ...

Neurotransmitter causes damage to the genetic material The Bonn researchers have now discovered that certain cells of the innate immune system, known as type 3 innate lymphoid cells (ILC3), are ...

"Our findings suggest that the increased number of interleukin-17A-producing ILC3 in the duodenum creates a local environment that favors the development of cancer in FAP patients," says co-lead ...

Biologics targeting ILC3-related pathways showed promise in managing Th2-low asthma, offering new treatment options for SRA. Investigators addressed the challenges and emerging strategies in managing ...

By employing complementary mouse models, the authors provided compelling evidence to support a mechanism through ILC3/IL-22/IL22R pathway. They further performed comprehensive single-cell sequencing ...

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At the same time, inflammatory RORγt+ T cells, called T helper (Th)17 cells, were dramatically increased in these mice—in part because many Tregs, bereft of the usual signals from their ILC3 ...

A population of c-kit + IL-17A + ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation , Science Translational Medicine, 17, 781, (2025). https://doi.org ...

In mice that develop colon cancers, blocking ILC3 signaling led to the growth of abnormally invasive and more aggressive tumors with poor outcome. And when colon tumors were implanted in mice with ...