Although axonal degeneration occurs in necrotic lesions, the role of axonopathy in myelination failure remains controversial for diffuse non-necrotic WMI, which is currently the major form of WMI. We ...

Recently, axonopathy, broadly defined as functional or structural defects in the axon or its terminal, has been established as a major early contributor to the genesis, progression, and symptomology ...

Significantly asymmetric or focal signs and symptoms due to toxin exposure are unusual, as most neurotoxins produce a generalized distal axonopathy with initial deficits in the feet, and only ...

However, constrictive axonopathy affected a few cases from 6 to 12 mo. postimplantation. A second electrode design with 571 holes and 27 ring electrodes was developed. The number of regenerated axons ...

AMN is characterized by chronic and progressive distal axonopathy involving the long tracts of the spinal cord and to a lesser extent the peripheral nerves resulting in progressive stiffness and ...

Decision letter after peer review: Thank you for submitting your article "Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5" for consideration by eLife. Your article has been ...

EAGLE—Eagle-based award-winning filmmakers, Justin Skeesuck and Patrick Gray, are having a virtual screening of their feature-length film, “I’ll Push You,” through Jan. 30, in partnership ...

"Leriglitazone reduced microglia activation in spinal cord tissues, which is important, as reduced axonal degeneration could translate into clinical benefits in AMN, in which the pathological hallmark ...