The San Francisco 49ers need a win in Week 11 over the Seattle Seahawks. Their injury situation may make it a significant uphill climb to a victory.

The spread opened at 49ers -7 but has moved slightly to -6.5. The line shift is likely a reflection of Seattle’s resilience despite their record. The total of 45.5 suggests expectations of a moderately high-scoring game, but the 49ers’ defense is one of the toughest units in the league, which could suppress scoring.