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Medscape3d
Comparative Pharmacokinetics of Two Fast-Dissolving Oral Ibuprofen Formulations and a Regular-Release Ibuprofen Tablet in Healthy Volunteers
Ibuprofen is a relatively weak acid (pka 4.4) and its solubility in water or at acid pHis very low. This results in a relatively long residence time in the acid environment of the stomach ...
C&EN25d
TCFH–NMI: Direct Access to N -Acyl Imidazoliums for Challenging Amide Bond Formations
Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please note: If you switch to a different device, you may be asked to login again with only ...
C&EN17d
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
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snmjournals.org17d
Synthesis and Preliminary Evaluation of Novel PSMA-targeting Small Molecule Drug Conjugate Using the Highly Potent PARP inhibitor Venadarib for Treatment of Prostate Cancer
DIPEA (15 eq.), DMF, rt, 16 h). PSMA-Vena-16 (k(2-Nal-Txa-β-Ala-d-d-k(SS-Vena)-(R)-DOTAGA)-EuE) was synthesized according to standard peptide coupling procedures. Glutathione (GSH) levels of PC-3, ...
snmjournals.org17d
18F-Labeling of Indocyanine Green Using 'Click Chemistry': A Dual-Modal Imaging Agent
The click chemistry reaction did not yield results when Cu(I) (CuI + DIPEA) was used directly as a catalyst for the reaction. However, the product could be obtained by forming Cu(I) in situ using CuSO ...
ahajournals.org15d
Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function
Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a ...