Ibuprofen is a relatively weak acid (pka 4.4) and its solubility in water or at acid pHis very low. This results in a relatively long residence time in the acid environment of the stomach ...

Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology (BIST), Av. Països Catalans 16, 43007 Tarragona, Spain Catalan Institute for Research and Advanced ...

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