One-year data suggest allogeneic stem cell-derived islet-cell therapy could become a future option for those with type 1 ...

To overcome biological barriers of islet transplantation, encapsulation strategies have been developed and robustly investigated. While islet encapsulation can prevent the need for immunosuppressants, ...

Vertex Pharmaceuticals is laying off 125 employees and consolidating their Rhode Island buildings after a failed diabetes ...

School of Energy Materials and Chemical Engineering, Hefei University, Hefei 230601, China Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization, College of Materials and ...

Over 500 million people worldwide suffer from diabetes—a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer's disease. At the heart of this ...

At the heart of this condition lies the dysfunction of pancreatic islets, the mini-organs called organoids responsible for regulating blood sugar, in both autoimmune type 1 diabetes and stress ...

Hypoxia in the pancreatic islets arises from inflammation, vascular dysfunction, hyperglycemia, and immune cell infiltration, creating a microenvironment that exacerbates β-cell dysfunction and ...

Learn more about eLife assessments Highly spatio-temporally resolved imaging of islet Ca 2+ oscillations on pancreatic tissue slices provides an in situ-like model for physiological and ...

An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander has for the first time developed an organoid model of human pluripotent stem cell-derived ...