Nonalcoholic fatty liver disease refers to a spectrum of diseases from hepatic steatosis to NASH, a condition where fat accumulation causes inflammation and hepatocyte injury leading to cirrhosis. [1] ...
Obstructive sleep apnea (OSA) is characterized by partial or complete airway obstruction during sleep. Prevalence is about 1.2%. [1] [1] Adenotonsillar hypertrophy and obesity are common risk factors ...
A 77-year-old woman was referred to a geriatric day hospital with concerns about mobility and falls, pain, constipation, cognition and polypharmacy. Comorbidities included cerebrovascular disease, ...
Smoking marijuana can increase clearance of some drugs Smoked marijuana increases the clearance of theophylline 40%. 1 Similar findings would be expected for other drugs metabolized by CYP1A2, such as ...
Background: Fragility fractures are a major health concern for older adults and can result in disability, admission to hospital and long-term care, and reduced quality of life. This Canadian Task ...
KEY POINTS In 2016, 270 204 people in Canada (excluding Quebec) were admitted to hospital for heart conditions, stroke and vascular cognitive impairment, including 107 391 women and 162 813 men, of ...
Background: Cancer surveillance data are essential to help understand where gaps exist and progress is being made in cancer control. We sought to summarize the expected impact of cancer in Canada in ...
William K. Silverstein, David N. Juurlink and Jonathan S. Zipursky ...
BACKGROUND: The appropriate timing of hip fracture surgery remains a matter of debate. We sought to estimate the effect of changes in timing policy and the proportion of deaths attributable to ...
Background: Pharmacogenomic testing to identify variations in genes that influence metabolism of antidepressant medications can enhance efficacy and reduce adverse effects of pharmacotherapy for major ...
Accidental intravascular injection of large doses of local anesthetic is the most important trigger of LAST1 A slow injection technique (< 1 mL/s) with frequent aspirations and ultrasonography ...
Major hemorrhage is a challenging clinical problem that can occur with traumatic injury, postpartum hemorrhage, major surgery and gastrointestinal bleeding. A massive hemorrhage protocol (MHP) should ...
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