Myocardial fibrosis is a major contributor to the development and progression of heart failure. Significant progress in the understanding of its pathobiology has led to the introduction and ...

The clinical presentations of early idiopathic Parkinson disease (IPD) substantially overlap with those of atypical parkinsonian syndromes such as multiple system atrophy (MSA) and progressive ...

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is highly expressed in cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to progression and worse ...

Prostate-specific membrane antigen (PSMA)–targeting radiopharmaceuticals, such as the novel [177Lu]Lu-HTK03170, present a promising therapeutic option for metastatic castration-resistant prostate ...

PET is a powerful molecular imaging technique that can provide functional information on living objects. However, the spatial resolution of PET imaging has been limited to around 1 mm, which makes it ...

RESULTS. Of the 126 patients analyzed, 14 (11%) had SARs ().Baseline complete blood count, demographics, and treatment history were analyzed with a univariable logistic regression model ().Age, prior ...

PSMA PET Imaging Protocols and Reporting. The recommended imaging protocols for 68 Ga-PSMA-11 and 18 F-DCFPyL are similar. In short, the administered activity, based on the prescribing information, is ...

In vivo visualization of inflammatory lesions has been revolutionized by PET with 18 F-FDG as a tracer and by MRI with gadolinium-labeled contrast media. Apart from other indications, 18 F-FDG PET and ...

Granzyme B. Granzyme B, a serine protease that induces apoptosis in target cells, is released by activated CD8-positive T cells and natural killer cells, in addition to some immunosuppressive cells () ...

Recent innovative strategies have dramatically redefined the therapeutic landscape for treating multiple myeloma patients. In particular, the development and application of immunotherapy and high-dose ...

Multiparametric MRI (mpMRI) and prostate-specific membrane antigen (PSMA) PET/CT are complementary imaging modalities used in the presurgical evaluation of patients with prostate cancer (PCa). The ...

In the past decade, the management of differentiated thyroid cancer (DTC) underwent a paradigm shift toward the use of risk stratification with the goal of maximizing the benefit and minimizing the ...