ICP-488 is an oral, potent, and selective TYK2 allosteric inhibitor. By binding to the JH2 domain, ICP-488 blocks the signal transduction of IL-23, IL-12, type 1 IFN, and other inflammatory cytokines, ...
Identification of Novel Inhibitors of Auxin-Induced Ca²⁺ Signaling via a Plant-Based Chemical Screen
Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K. Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman ...
Edited by: Paul Smaglik D.R. Alessi, A. Cuenda, P. Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in ...
Recludix Pharma Inc. has disclosed signal transducer and activator of transcription 3 (STAT3) and/or STAT6 inhibitors reported to be useful for the treatment of cancer and inflammatory disorders.
ROCKVILLE, Md. and SUZHOU, China, Nov. 24, 2025 (GLOBE NEWSWIRE) -- Ascentage Pharma Group International Inc. (NASDAQ: AAPG; HKEX: 6855), a global, commercial stage ...
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