Here we show that bacteria engineered to produce a short hairpin RNA (shRNA) targeting a mammalian gene induce trans-kingdom RNAi in vitro and in vivo.

RNA serves a wide variety of roles within a cell, carrying out catalytic, regulatory, structural and genetic transferal functions. A type of artificial RNA, called short hairpin RNA (shRNA ...

Gene Therapy - Therapeutic short hairpin RNA expression in the liver: viral targets and vectors. Skip to main content. Thank you for visiting nature.com.

Horizon Discovery’s microRNA-adapted short hairpin RNAs are contributing to the development of chimeric antigen receptor T-cell therapies that may be less apt to cause graft-versus- host disease.

Effect of short hairpin RNA targeting of fibroblast activation protein on tumor growth and angiogenesis in a 4T1 murine breast cancer model. Fan Cai, Feng Peng, Chunting Wang, Zhiyong Li, Shuang Xian, ...

Background: Human papillomavirus type 16 is identified in almost 50% of the cases of OSCC. The E6 and E7 genes of HPVs encode oncoproteins that bind and degrade the tumor suppressor proteins p53 and ...

Short hairpin RNA: an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi). Expression of shRNA in cells is typically ...

COG-201 uses short hairpin RNA (shRNA) to target and reduce the expression of the serotonin 5-HT2A receptor in the brain. This receptor plays a crucial role in regulating mood, anxiety, and ...

HKUST researchers reveal RNA elements that enhance the cleavage of pre-miRNAs/shRNAs by DICER Peer-Reviewed Publication. Hong Kong University of Science and Technology ...

The Duke-developed hairpin lock aims to solve both problems. The common factor to all CRISPR systems is the guide RNA, so the team added an extra 20 nucleotides to the end of it.

The switch from fetal to adult hemoglobin expression in humans is related to the active repression of HbF expression by BCL11A.A self-inactivating lentivirus vector with a short hairpin RNA ...

Short hairpin RNA (shRNA) are produced in the nucleus of transduced or transfected cells which lead to the formation of hairpin structures. These hairpin structures make a loop by the pairing of ...