Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately ...

Salt-sensitive hypertension arises when the kidney’s ability to excrete sodium is impaired, requiring higher arterial pressure to eliminate a given sodium load. In healthy individuals, acute increases ...

Patients with high genetic risk for hypertension who frequently added salt to their food had especially increased risk of CKD. Individuals with a higher polygenic risk score for hypertension ...

In the total population, 51% of those patients with hypertension are salt-sensitive, and among normotensives, 26% are salt-sensitive. Risk factors for salt-sensitivity include black race, intrinsic ...

Excessive salt intake leads to ill-health effects, of which hypertension (high blood pressure) stands as the most serious. Yet is the treatment offered the most effective? New research suggests an ...