Remdesivir is a member of one of the oldest ... Slight differences in the chemical structure of these analogues from naturally occurring compounds make them effective as drugs.

One of remdesivir's flaws is its (possibly toxic) high dosage over a short timeframe, which contributes to adverse side effects. By tweaking the drug molecule's structure, scientists may be able ...

The structure of remdesivir has been retrieved from PubChem ... to dock remdesivir to the Mpro and RdRp binding sites, while molecular dynamics simulation was conducted to capture motion ...

Remdesivir works by disrupting the virus’s ability to replicate, but its exact mechanism has remained a mystery. Using advanced computational simulations, researchers at the Pritzker School of ...

A team of Chinese scientists have reported the high-resolution cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2, the infective virus of COVID-19. The research ...

an instructor in clinical medicine and associate research scientist in the Department of Biochemistry and Molecular Biophysics at Columbia University. Griffin called remdesivir a “very effective ...

His team developed its own software that scans a chemical recipe—like remdesivir—and puts the instructions into XDL, which then directs the chemputer to execute actions with standard heaters ...

"It's important to understand how remdesivir works at a molecular level," said Prof. Juan de Pablo, who led the research. "Now that we see that it is effective, and other drugs are not as ...