have this dMMR characteristic These tumors are often labeled “MSI-high” (microsatellite instability-high), which also signals a potential response to immune checkpoint inhibitors like ...

The absence of an allele-span effect is problematic for theories invoking heterozygote instability as a factor increasing the rate of microsatellite evolution in large populations 11; however ...

Results from the study were showcased in a poster presentation titled, Use of Biosimulation to Predict Immune Checkpoint Inhibitor Resistance in Patients with High Microsatellite Instability as ...

Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability ...

The treatment is recommended for adults with untreated, unresectable, or metastatic colorectal cancer that shows high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR).

it is part of a wider group of therapies targeting the DNA damage response for patients with solid tumors and genetic changes known as high microsatellite instability (MSI) or deficient mismatch ...