Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability ...

Microsatellite instability (MSI), which results from defects in the DNA mismatch repair system, is an important biomarker in colorectal cancer. While the MSI-high (MSI-H) status predicts response to ...

An evaluation of nearly 19,000 patients with metastatic colorectal cancer supported clinical trial data that immunotherapy ...

Medically reviewed by Jamin Brahmbhatt, MD Metastatic castration-resistant prostate cancer (mCRPC) is prostate cancer that has spread beyond the prostate and is no longer responding to treatments that ...

The firm is prioritizing development of its anti-DKK1 antibody sirexatamab following promising Phase II results in microsatellite-stable colorectal cancer.

A panelist discusses how multiple molecular biomarkers beyond BRCA and homologous recombination deficiency (HRD) testing are ...

ProDx MSI Detection Kit will be used to characterize colorectal cancers for microsatellite instability as an aid to identify patients that would benefit from additional genetic testing to diagnose ...

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors ...