When functional, a lysosome can break down large sugars into small sugars, which are then used as an energy source. In LSDs, these macrophage lysosomes become swollen and filled with waste.

The role of macrophages in the immune system and LSDs was not well known, but the new research published in Nature Cell Biology in an article titled, “Pressure sensing of lysosomes enables ...

The yet unknown phago-lysosome-mitochondria crosstalk in macrophages leads to a better understanding of how immune cells work and may identify new intervention points for treating infectious diseases.

When functional, a lysosome can break down large sugars into small sugars, which are then used as an energy source. In LSDs, these macrophage lysosomes become swollen and filled with waste.

The fused lysosome and phagosome is referred to as a phagolysosome. Most macrophages can live for several months and can kill hundreds of different bacteria before they die. In this way ...

In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies). This gene encodes for the ...