The Smad2/3 pathway plays a key role in mediating TGF-β1 inhibition of branching morphogenesis and induction of connective tissue growth factor (CTGF) expression in embryonic lungs. Because a number ...
Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...
Protein kinases are biologically important enzymes involved in intracellular signaling functions. The largest family of enzymes encoded for, they catalyze the phosphorylation of target substrate ...