Sal Maiorana’s take: The Bills have two key advantages: they’re at home and the game matters more for their playoff hopes. Buffalo is 16-1 at home since early 2024, while the Eagles—already locked into at least the No. 3 NFC seed—are strong on the road (5-3). It’ll be tough, but Sal believes the Bills will pull it off.

In a game with a special Saturday evening kickoff in Week 16, the Washington Commanders play host to the division rival Philadelphia Eagles.