The novel enzymes are further improved by extensive saturation mutagenesis and other directed-evolution approaches ... variants with increased stability and containing 11–14 amino acid ...

Their findings highlight how global cooling events influenced enzyme evolution. Life has evolved ... of the ancestral enzymes and used site-directed mutagenesis, a technique that allows precise ...

Early successes with this approach primarily improved the stability of enzymes ... further optimization with directed ...

In comparison to other methods such as directed evolution, rational design is less time ... this strategy to engineer protein-based vaccines, antibodies, and enzymes with high thermal stability and ...

If your work involves protein or pathway engineering, don’t miss this webinar illustrating the approach that Cellibre, a cellular agriculture company leveraged to significantly accelerate their Design ...

Arnold pioneered directed enzyme evolution and has used directed evolution to optimize biocatalysts for applications in alternative energy, chemicals, and medicine. Her methods are used throughout the ...

Early successes with this approach primarily improved the stability of enzymes ... further optimization with directed evolution to reach speeds common among natural enzymes.