The Santoro et al study is based on the results of an international EAP that provided patients with mesothelioma with access to single-agent pemetrexed or to cisplatin/pemetrexed or carboplatin ...

The current standard of first-line chemotherapy for MPM is cisplatin or carboplatin in combination with pemetrexed, an antifolate compound that has been shown to increase the cytotoxic effects of ...

Pemetrexed disodium in combination with cisplatin is indicated for the treatment of patients with MPM whose disease is unresectable or who are otherwise not candidates for curative surgery 5.

A phase II trial of pemetrexed with either cisplatin or carboplatin in patients with extensive-stage SCLC demonstrated a median overall survival of 10.4 months with relatively modest toxic effects.

In this interview, they discuss their research. Cisplatin is a chemotherapy drug used globally for the treatment of several cancers; however, it is also highly toxic to the kidneys. Beyond general ...