The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Protein disaggregation is a critical cellular process wherein misfolded or aggregated proteins are solubilised and, in many cases, returned to their native configurations. Chaperone systems, including ...

New research describes a 'chaperone' protein that delivers zinc, a trace element essential for survival in all living things, to where it's needed. The chaperone could be especially important when ...

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells. These aggregates, if accumulated, may contribute to age-related disorders, including ...

Figure 1: The molecular chaperone network. Client proteins rely on sequential interactions with chaperones, cochaperones, and chaperonins to fold into an active, native, state. Thus, functional levels ...

The journey by which proteins navigate their energy landscapes to their native structures is complex, involving (and sometimes requiring) many cellular factors and processes operating in partnership ...

The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...

A new study has found that treatment with a ‘chemical chaperone’ assists in reducing the accumulation of protein plaques and restores cognitive functioning in mouse models of Alzheimer’s disease. The ...

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. A study by ...

Miroslav Radman is founder and scientific director of the Mediterranean Institute for Life Sciences (MedILS). The MedILS has received funding from the NAOS company for several research collaborations.