Mast cell secretory granules are lysosome-like organelles that contain a large panel of preformed bioactive constituents, including lysosomal hydrolases, amines, cytokines, proteases and ...

Despite the wealth of knowledge about the anatomy and synaptic physiology of this system, nothing is known how granule cell activity influences the activity of CA3 targets in the intact network in ...

These granules, which are formed by a dsRNA helicase called DHX9, are passed on to daughter cells along with UV-damaged RNA. Ordinarily, DHX9 remains in the nucleus unless the cell is exposed to ...

T-cell large granular lymphocytic (T-LGL) leukemia affects white blood cells called lymphocytes, which are part of the body’s immune system. The “T” means the leukemia starts in T cells.

An oxygen dropoff, overheating, or an invading toxin can trigger the cellular stress response – a cascade of molecular changes that are the cell’s last-ditch effort to survive. Among these survival ...

Called gelatin methacryloyl (GelMA) granular hydrogel scaffolds, the materials comprise hydrogel microparticles known as microgels that can be squeezed against each other and confine cells among ...

In summary, it is clear that an analysis of the stem cell publication record can yield unique information about different market segments in a deeply granular manner that can be used as a metric ...

Therefore, the team developed a groundbreaking droplet extraction method to isolate these granules directly from cells and analyze their content. Surprisingly, the team found that the DHX9 granules, ...

Jointly with other components, the Staufen2 and Argonaute RNA-binding proteins form RNA granules in the cytoplasm. A team led by LMU cell biologist Prof. Michael Kiebler has now shown for the ...

In regulating these complex processes, so-called RNA granules – small aggregates of various RNA binding proteins and mRNA – play an important role. In a paper just published in the journal Nature ...

Therapy candidates chosen for lead projects targeting mast cell driven diseases Therapy candidates chosen for lead projects targeting mast cell driven diseases Granular Therapeutics – a company ...