More information: Koustav Roy et al, Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors ...

et al. (2024). Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications.

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

Oxford, UK-based Exscientia has been working with German biotech Evotec on the adenosine A2a receptor antagonist, which is being tested as a treatment for adult patients with advanced solid tumours.

The sensor, named Hypersensitive intracellular adenosine Sensor (HypnoS), allows for the monitoring of iAdo dynamics during seizures or sleep-wake cycles with high spatiotemporal resolution in the ...

KW-6356 has a higher affinity and selectivity for adenosine A2A receptors, leading Kyowa Kiri to speculate that it could obtain approval for a wider group of Parkinson's patients than Nourianz.